Recombinant human lectins are versatile tools in probing physiologically relevant glycoprofile and enriching target cells by specific glycosylated states. At GlycoGenetics, we use various recombinant expression platforms in a goal to produce a comprehensive collection of >200 of known human lectins. This lectin collection, in combination with our Human Glycoprofile Collection, allows us to map the native human lectin-glycan interaction in a systematic manner. 

Exploring complex glycans for crucial glycogenes linked to biology and disease is challenging. Our solution is a genetically tractable cell-based glycan display platform. This highly adaptable glycogenomics platform allows us to discover new biomarkers and drug targets through decoding biologically meaningful glycoprofiles.  This platform aids in identifying vital glycogenes and has applications in:

Beyond glycogenomics, GlycoGenetics is a dedicated toolmaker. We have created a recombination-based mutagenesis platform called RIFFLE. RIFFLE allows us to capture and shuffle functional DNA fragments in a highly efficient manner. Combining RIFFLE with existing directed evolution approaches, we aim to improve existing lectin reagents for advanced applications. Beyond lectin engineering,  RIFFLE is capable of shuffling large DNA fragments for pathway engineering.