The lack of tools to probe the structures of glycans and thus their underlying biological roles is a critical challenge for the research of glycobiology. In Glycogenetics, we leverage state-of-the-art genetics to establish core technology platforms for molecular and cellular engineering. Through the iterative discovery cycles on these engineering platforms, we develop innovative toolsets for detection, enrichment, and display. Together, these efforts allow us to probe the complexities and unlock untapped potentials of glycobiology.

Lectins are natural glycan-binding proteins. Human lectins are critical sensors to interpret glycoforms into physiological cues. At Glycogenetics, our first product pipeline is to recombinantly produce a comprehensive collection of human lectins as versatile tools in probing and enriching biomolecules of specific glycosylated states. This human lectin collection, in combination with our in-house engineered cell lines collection—targeted glycogene-knock-out and -overexpression models—allows us to genetically curate binding profiles of each lectin. This lectin-based glycoprofilng platform not only provides researchers more information when selecting the most suitable lectin for their applications, but it also allows us to curate lectins by their capability of telling specific genetic backgrounds and thus related diseases.  

Furthermore, by combining the glycoprofiling platform and the molecular engineering platform, we can iteratively discover and improve lectins for dedicated uses. The resulting continuous lectin curation and optimization cycle is fully integrated with our bioprocessing optimization and quality control measures as our core to achieve production excellency. Our goal is to empower the glycobiology community with high-quality, functionally validated lectin-based tools tailored for cutting-edge exploration.